When you take C l o p S Nano Lotion 20 ml, it works by blocking the production of certain chemical messengers (prostaglandins) that are responsible for making the skin red, swollen, and itchy. It softens, separates, and causes desquamation of the cornified epithelium or horny layer of skin and breaks down the clumps of keratin, removes dead skin cells and helps in the softening of the skin.